KMID : 0370219970410040462
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Yakhak Hoeji 1997 Volume.41 No. 4 p.462 ~ p.472
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Comparison of the Activities of Novel ¥â-Lactamase Inhibitors , 6-Exomethylene Penamsulfones , with Other ¥â-Lactamase Inhibitors as Combined with ¥â-Lactam Antibiotics ( I )
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¹Ú°èȯ/Park KW
±è±âÈ£/±è¹Ì¿µ/ÀÓä¿í/ÀÓöºÎ/Kim KH/Kim MY/Im CU/Yim CB
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Abstract
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In this approach, the antimicrobial activities of the compounds were compared with the beta-lactam antibiotics against beta-lactamase producing strains in vitro. Heteroc yclyl exomethylenepenam derivatives were several numbers of 6-exomethylenepenam sodiums (CH1240, CH1245, CH1250, CH2140, CH2145, CH2150). The inhibitory concentraion assay of six compounds were compared with clavulanic acid, sulbactam, tazobactam. Clavulanic acid, sulbactam and tazobactam are used as inhibitors of a variety of plasmid-mediated beta-lactamases. In vitro beta-lactamase inhibitory assay, CH1240 and CH2140 were more active than clavulanic acid, sulbactam and tazobactam against beta-lactamases overally. And in vitro comparative antimicrobial susceptibility test of six inhibitors were performed with mixed forms of ampicillin, cefotaxime, amoxicillin, ticarcillin, piperacillin, cefoperazone against beta-lactamase producing 31 species strains. Consequently CH2140 and CH1240 among the six compounds enhanced the activity of the beta-lactams for 31 beta-lactamase producing strains.
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KEYWORD
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